Skin rash
There’s a very singular skin rash called necrolytic migratory erythema, which appears in pancreatic cancers that synthesize excessive amounts of the hormone glucagon. This rash usually appears in the buttocks, lower abdomen, and lower extremities. It starts with red patches with a central blister that eventually crusts and heals in cycles of 10 days, leaving the skin with a darker color. This rash causes excessive itching, and it might cause pain as well.