Loss of appetite
Appetite changes are common in most types of cancer, regardless of their location. They result from systemic inflammation and how inflammatory cytokines are perceived by the brain. They give a specific signal that suppresses appetite and contributes to a wasting syndrome called cachexia.
Loss of appetite makes kidney cancer patients more susceptible to nutritional deficiencies and contributes to other symptoms, such as chronic fatigue, anemia, and weight loss. It often appears at a later stage of the disease, and it is associated with severe complications.