The severe cases of kidney failure result in the development of coma in the patients, which becomes a serious health concern. According to the researchers, in the condition of acute kidney failure, the patients become more vulnerable to the development of coma and the mental status of the person also affects a lot. The buildup of the toxins and waste products affects the normal functioning of the brain by providing the brain with lesser oxygen. The less availability of oxygen to the brain results in the slower processing of the stimuli, and there is also delay in the response. The person loses his or his consciousness and goes with the state of coma.