Extreme pallor
Besides nausea, exhaustion, and shortness of breath, in patients with acute and some chronic leukemia, paleness can be a symptom of leukemia-related anemia. Experts at Mayoclinic say that the development of extreme paleness means the disease has already progressed to advanced stages. It turns your skin, the palms of the hands, soles of the feet, and sclera of the eyes yellow.
Persistent anemia can also cause other associated symptoms such as shortness of breath, feeling tired, and easy fatiguability.