Even though this is a symptom found in many health problems, in the case of individuals with liver disease, the situation is different. In this case, we refer to central fatigue. It shows up within the central nervous system (CNS), and it can be defined as a difficulty for performing physical activities (or mental ones), where self-motivation is required. The individual’s responses to internal cues is affected as well.
In fact, research associates central fatigue with a higher sensation of effort when an individual undertakes any tasks. In other words, neurotransmission within the brain gets altered in people with liver issues. Of course, liver diseases involve many different interactions among biological, psychosocial and behavioural processes, and they can all turn into the clinical expression of fatigue for an individual with liver failure.